MyBioSource.com's MPZL2 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The MPZL2 Antibody (Center) was generated using EVA1, and MPZL2 as the antigen and it reacts with Human.
Description
Thymus development depends on a complex series of
interactions between thymocytes and the stromal component of the
organ. Epithelial V-like antigen (EVA) is expressed in thymus
epithelium and strongly downregulated by thymocyte developmental
progression. This gene is expressed in the thymus and in several
epithelial structures early in embryogenesis. It is highly
homologous to the myelin protein zero and, in thymus-derived
epithelial cell lines, is poorly soluble in nonionic detergents,
strongly suggesting an association to the cytoskeleton. Its
capacity to mediate cell adhesion through a homophilic interaction
and its selective regulation by T cell maturation might imply the
participation of EVA in the earliest phases of thymus
organogenesis. The protein bears a characteristic V-type domain and
two potential N-glycosylation sites in the extracellular domain; a
putative serine phosphorylation site for casein kinase 2 is also
present in the cytoplasmic tail. Two transcript variants encoding
the same protein have been found for this gene. [provided by
RefSeq]